For an oocyte for being Completely ready for fertilization and progress into an embryo, the appropriate set of genes really should be turned on. Namekawa suspected that this pre-programming in the oocyte genome occurs in a number of stages — the initial a single starting up round the time a feminine is born. He thought that chromatin remodeling proteins did A lot of the get the job done, by shifting spools all around.
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Utilizing the GCRLE grant, Munakata and Namekawa will appear more carefully at how oocytes are genomically primed and stored for afterwards use. They are going to investigate the job of a chromatin remodeler in oocyte survival and fertility.
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This could assist reveal why more mature women are more likely to bear youngsters with chromosomal Issues like Down Syndrome, in which an extra copy of chromosome 21 finds its way into an oocyte — and later on, an embryo.
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This protein may well “set up and maintain the chromatin point out,” states Namekawa — keeping the spools set up as well as the oocytes genetically primed as the mouse matures.
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